Defective Kinesin Heavy Chain Behavior in Mouse Kinesin Light Chain Mutants
نویسندگان
چکیده
منابع مشابه
Defective Kinesin Heavy Chain Behavior in Mouse Kinesin Light Chain Mutants
Conventional kinesin, kinesin-I, is a heterotetramer of two kinesin heavy chain (KHC) subunits (KIF5A, KIF5B, or KIF5C) and two kinesin light chain (KLC) subunits. While KHC contains the motor activity, the role of KLC remains unknown. It has been suggested that KLC is involved in either modulation of KHC activity or in cargo binding. Previously, we characterized KLC genes in mouse (Rahman, A.,...
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In Drosophila, the asymmetries that specify the embryonic axes are established early during oogenesis in a process that requires the precise localisation of several transcripts (Riechmann and Ephrussi, 2001; van Eeden and St Johnston, 1999). The localisation of oskar mRNA to the posterior pole of the oocyte specifies where the pole plasm forms, and thus where the abdomen and the germ line will ...
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The mechanochemical ATPase kinesin is thought to move membrane-bounded organelles along microtubules in fast axonal transport. However, fast transport includes several classes of organelles moving at rates that differ by an order of magnitude. Further, the fact that cytoplasmic forms of kinesin exist suggests that kinesins might move cytoplasmic structures such as the cytoskeleton. To define ce...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1999
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.146.6.1277